Description

26,26,26,27,27,27-Hexafluoro-1,23,25-Trihydroxyvitamin D3 is a high-purity, fluorinated analog of the active form of Vitamin D3, designed for advanced research and pharmaceutical development. This compound is critical for studying the structure-activity relationships of vitamin D receptor (VDR) ligands and developing novel therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, oncology, and metabolic disease research.

Application

• Biochemical Research: A key reference standard and tool compound for investigating the Vitamin D endocrine system, VDR activation, and gene regulation.
• Pharmaceutical R&D: Serves as a crucial intermediate or active pharmaceutical ingredient (API) in the development of novel therapies targeting osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Used in preclinical studies to explore calcium and phosphate homeostasis, cell differentiation, and immune modulation.
• Analytical Standard: Employed as a high-purity calibration standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.

Basic Information

Product Name	26,26,26,27,27,27-Hexafluoro-1,23,25-Trihydroxyvitamin D3
CAS No.	114489-80-4
Molecular Formula	C₂₇H₃₈F₆O₃
Molecular Weight	524.59 g/mol
Synonyms	F6-1,23,25-(OH)3D3; Hexafluorocalcitriol; 26,26,26,27,27,27-Hexafluoro-1α,23S,25-trihydroxycholecalciferol; 1,23,25-Trihydroxy-26,26,26,27,27,27-hexafluorovitamin D3; Falecalcitriol analog; (1S,3R,7E,20R)-5-[2-(1,1-Difluoro-2-{[(1R,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]amino}-2-oxoethylidene)-9,10-secocholesta-5,7,10(19)-trien-3-yl]oxy]-2,2-difluoro-5-oxopentanoic acid (IUPAC); 26,26,26,27,27,27-Hexafluoro-1α,23S,25-trihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our 26,26,26,27,27,27-Hexafluoro-1,23,25-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the material should be handled in a controlled, dry environment and allowed to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.