Description

1-Hydroxy-24,24-Dimethyl-22-Dehydrovitamin D3 is a synthetic analog of vitamin D, specifically engineered to modulate calcium and phosphate metabolism. This compound is of significant interest for its potent biological activity and serves as a key intermediate in the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on endocrinology, metabolic bone disorders, and oncology research.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced vitamin D analogs for therapeutic applications.
• Biochemical Research: Used as a reference standard and active compound in studies of vitamin D receptor (VDR) signaling pathways.
• Drug Discovery: Serves as a lead compound for developing new treatments for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Metabolic Studies: Employed in preclinical research to investigate the effects on calcium homeostasis and bone mineralization.
• Fine Chemical Synthesis: A high-value intermediate for custom synthesis and contract manufacturing of specialized active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Hydroxy-24,24-Dimethyl-22-Dehydrovitamin D3
CAS No.	104211-64-5
Molecular Formula	C29H46O2
Molecular Weight	426.68 g/mol
Synonyms	1α-Hydroxy-24,24-dimethyl-22-dehydrovitamin D3; 1α-OH-24,24-Dimethyl-22-Dehydrocholecalciferol; 24,24-Dimethyl-1α-hydroxy-22-dehydrovitamin D3; Falecalcitriol Intermediate; 1α,24(OH)2-24,24-Dimethyl-22-ene Vitamin D3; (1α,3β,5Z,7E,22E)-9,10-Secocholesta-5,7,10(19),22-tetraene-1,3,24-triol, 24,24-dimethyl-; ED-71 Intermediate
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-24,24-Dimethyl-22-Dehydrovitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.