Description

24,24-Difluoro-24-Homo-1,25-Dihydroxyvitamin D3 is a high-purity, fluorinated analog of the active form of Vitamin D3, designed for advanced research and pharmaceutical development. This compound is valued for its enhanced metabolic stability and potent biological activity, making it a critical intermediate in the synthesis of novel therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of high-value active pharmaceutical ingredients (APIs) targeting calcium metabolism disorders, oncology, and dermatology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of next-generation Vitamin D receptor (VDR) agonists and antagonists.
• Biochemical Research: Used as a reference standard and probe in studies of Vitamin D metabolism, receptor binding affinity, and gene regulation.
• Drug Discovery: Serves as a lead compound for developing treatments for osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Investigates the impact of fluorination on the pharmacokinetic and pharmacodynamic profile of secosteroids.
• API Development: Employed in the cGMP-compliant manufacturing of specialized, high-potency APIs.

Basic Information

Product Name	24,24-Difluoro-24-Homo-1,25-Dihydroxyvitamin D3
CAS No.	115540-42-6
Molecular Formula	C₂₈H₄₂F₂O₃
Molecular Weight	452.64 g/mol
Synonyms	1,25-Dihydroxy-24,24-difluoro-24-homovitamin D3; 24,24-Difluoro-1α,25-dihydroxy-24-homovitamin D3; 24,24-Difluoro-1α,25-dihydroxy-24-homo-cholecalciferol; Falecalcitriol analog; 24,24-Difluoro-24-homo-calcitriol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-4-ethyl-1,5-dihydroxy-6,6-difluoro-5-methylhex-2-en-1-yl]-7a-methyloctahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 24,24-Difluoro-24-Homo-1,25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for research and pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.