Description

26,26,26,27,27-Pentafluoro-1-Hydroxy-27-Methoxyvitamin D3 is a fluorinated analog of the active form of vitamin D, designed for enhanced metabolic stability and targeted biological activity. This high-purity synthetic intermediate is critical for advanced pharmaceutical research and development, particularly in studying vitamin D receptor (VDR) pathways. It is primarily utilized by research institutions and pharmaceutical companies developing novel therapeutics for conditions related to calcium regulation, cell differentiation, and immune modulation.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel vitamin D analogs for drug development.
• Biochemical Research: Used as a reference standard and probe in studies of vitamin D receptor (VDR) binding affinity and activation.
• Metabolic Pathway Studies: Investigates the impact of fluorination on the metabolic stability and half-life of vitamin D compounds.
• Preclinical Development: Serves as an active pharmaceutical ingredient (API) intermediate for evaluating efficacy in models of osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Chemical Biology: A tool compound for exploring structure-activity relationships (SAR) in the design of selective VDR modulators.

Basic Information

Product Name	26,26,26,27,27-Pentafluoro-1-Hydroxy-27-Methoxyvitamin D3
CAS No.	119839-97-3
Molecular Formula	C₂₈H₃₉F₅O₃
Molecular Weight	518.61 g/mol
Synonyms	1α-Hydroxy-26,26,26,27,27-pentafluoro-27-methoxyvitamin D3; 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxy-cholecalciferol; 1α-OH-26,26,26,27,27-Pentafluoro-27-OMe-D3; Falecalcitriol intermediate; Fluorinated vitamin D3 analog; 26,27-Hexafluorocalcitriol derivative; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,26-triol, 26,26,26,27,27-pentafluoro-27-methoxy-
EINECS	Contact for details

Quality Control

Our 26,26,26,27,27-Pentafluoro-1-Hydroxy-27-Methoxyvitamin D3 is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each batch to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.