Description

1,24,25,28-Tetrahydroxyergocalciferol is a highly functionalized derivative of ergocalciferol (vitamin D2), representing a key intermediate in the synthesis of advanced vitamin D analogs. This compound matters for its critical role in pharmaceutical research and development, particularly in the study of vitamin D receptor (VDR) activity and the creation of novel therapeutics. It is primarily needed by research institutions and pharmaceutical companies focused on developing treatments for conditions related to calcium metabolism, bone health, and cell differentiation.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and research tool in studies of vitamin D metabolism, receptor binding, and signaling pathways.
• Drug Discovery: Serves as a key starting material in medicinal chemistry programs aimed at developing new therapies for osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Employed in laboratory investigations to understand the enzymatic hydroxylation pathways of vitamin D2.
• Reference Material: Utilized in analytical laboratories for method development and calibration in HPLC and LC-MS assays for vitamin D compounds.

Basic Information

Product Name	1,24,25,28-Tetrahydroxyergocalciferol
CAS No.	103305-10-8
Molecular Formula	C₂₈H₄₄O₅
Molecular Weight	460.65 g/mol
Synonyms	1,24,25,28-Tetrahydroxyvitamin D2; 1α,24R,25,28-Tetrahydroxyergocalciferol; 1α,24R,25-Trihydroxy-28-hydroxyergocalciferol; Vitamin D2 tetrol; 1,24,25,28-Tetrahydroxycalciferol; ER-103305-10-8
EINECS	Contact for details

Quality Control

Our 1,24,25,28-Tetrahydroxyergocalciferol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to its light-sensitive and hygroscopic nature. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.