Description

Pparδ Agonist 2 CAS NO 870884-12-1 is a potent and selective small molecule agonist for the Peroxisome Proliferator-Activated Receptor Delta (PPARδ), a key nuclear receptor involved in regulating lipid metabolism and energy homeostasis. This compound is a critical research tool for studying metabolic disorders, inflammation, and cellular differentiation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutics for conditions such as dyslipidemia, diabetes, and muscular diseases.

Application

• Pharmaceutical Research & Development: Serves as a reference standard and active pharmacological agent in preclinical studies for metabolic and inflammatory diseases.
• Mechanism of Action Studies: Used to elucidate the role of PPARδ signaling in gene expression, fatty acid oxidation, and insulin sensitization.
• High-Throughput Screening (HTS): Employed as a positive control in cell-based assays to validate screening platforms targeting the PPARδ receptor.
• Biochemical Assay Development: Acts as a key ligand in developing and optimizing in vitro binding and transactivation assays for PPARδ.
• Academic Research: Facilitates fundamental biological research into energy metabolism, muscle physiology, and macrophage polarization.
• Drug Discovery Programs: A starting point for medicinal chemistry efforts aimed at creating new PPARδ-targeted drug candidates with improved profiles.

Basic Information

Product Name	Pparδ Agonist 2
CAS No.	870884-12-1
Molecular Formula	C21H20F3NO3S
Molecular Weight	423.45 g/mol
Synonyms	GW 501516; GW501516; GSK-516; Endurobol; PPARδ Agonist GW501516; 2-Methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methylthio)phenoxyacetic Acid; (2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)thio)phenoxy)acetic Acid
EINECS	Contact for details

Quality Control

Our Pparδ Agonist 2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.