Description

A-770041 CAS NO 869748-10-7 is a potent and selective small molecule inhibitor of the NEDD8-activating enzyme (NAE), a key regulator of the neddylation pathway. This compound matters as a critical research tool for investigating protein degradation, cell cycle progression, and the ubiquitin-proteasome system in various disease models. It is primarily needed by pharmaceutical R&D teams and academic researchers focused on oncology, neurodegenerative diseases, and the development of targeted protein degradation therapies.

Application

• Biochemical Research: Used as a selective inhibitor to study the neddylation pathway and its role in cullin-RING ligase (CRL) activation.
• Oncology Research: Investigated for its potential to induce cancer cell apoptosis by disrupting the degradation of specific tumor suppressor proteins.
• Cell Biology Studies: Applied in vitro to understand cell cycle regulation, DNA damage response, and signal transduction mechanisms.
• Drug Discovery: Serves as a reference compound and a starting point for the development of novel NAE inhibitors and PROTACs (Proteolysis Targeting Chimeras).
• Neurodegenerative Disease Research: Explored in models of diseases like Alzheimer's to understand protein aggregation and clearance pathways.

Basic Information

Product Name	A-770041
CAS No.	869748-10-7
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	N-[(1S,2R)-2-Hydroxy-1-(hydroxymethyl)-2-phenylethyl]-4-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide; A770041; A 770041; NEDD8 Activating Enzyme Inhibitor; MLN4924 Analog
EINECS	Contact for details

Quality Control

Our A-770041 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.