Description

Sb 203580 (Hydrochloride) is a potent and selective cell-permeable inhibitor of p38 MAPK (mitogen-activated protein kinase) alpha and beta isoforms. This compound is a critical research tool for studying cellular stress response pathways, inflammation, and apoptosis. It is primarily utilized by researchers and scientists in the fields of biochemistry, cell biology, and pharmaceutical development for target validation and mechanistic studies.

Application

• Biochemical Research: A key reagent for investigating the p38 MAPK signaling pathway and its role in cellular processes.
• Drug Discovery: Used in high-throughput screening and target validation studies for inflammatory and autoimmune diseases.
• Cell Biology Studies: Employed to elucidate mechanisms of apoptosis, cytokine production, and cellular differentiation.
• Academic Research: Essential for university and institutional labs focusing on signal transduction and kinase biology.
• Pharmaceutical R&D: Serves as a reference standard and pharmacological tool in preclinical development stages.

Basic Information

Product Name	Sb 203580 (Hydrochloride)
CAS No.	869185-85-3
Molecular Formula	C21H19FN4O2 • HCl
Molecular Weight	430.86 g/mol (Hydrochloride salt)
Synonyms	SB 203580 HCl; SB-203580 hydrochloride; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole hydrochloride; p38 MAP Kinase Inhibitor SB 203580 (hydrochloride); SB203580; SB 203580; 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our Sb 203580 (Hydrochloride) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity and purity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.