Description

1-Propionyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile electrophilic reagent for introducing the sulfonamide moiety, enabling the creation of complex molecules with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including potential kinase inhibitors and receptor antagonists.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides that utilize the sulfonamide functional group for enhanced efficacy.
• Chemical Biology: Serves as a probe or linker reagent for protein labeling and bioconjugation studies due to its reactivity with amines.
• Material Science: Intermediate in the synthesis of specialty polymers and functional materials requiring sulfonamide linkages.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	1-Propionyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride
CAS No.	868963-99-9
Molecular Formula	C11H12ClNO3S
Molecular Weight	273.73 g/mol
Synonyms	5-(Chlorosulfonyl)-1-propionyl-2,3-dihydro-1H-indole; 1H-Indole-5-sulfonyl chloride, 2,3-dihydro-1-propionyl-; 1-Propionylindoline-5-sulfonyl chloride; 2,3-Dihydro-1-propionyl-1H-indole-5-sulfonyl chloride; N-Propionyl-2,3-dihydro-1H-indole-5-sulfonyl chloride; Propionyl indoline-5-sulfonyl chloride; 868963-99-9
EINECS	Contact for details

Quality Control

Our 1-Propionyl-2,3-Dihydro-1H-Indole-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.