Description

Setipiprant is a potent and selective antagonist of the prostaglandin D2 (PGD2) receptor, specifically the CRTH2 receptor. This targeted mechanism of action makes it a valuable research compound for investigating inflammatory pathways and related conditions. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the life sciences sector. The compound is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for preclinical and clinical development programs.

Application

• Pharmaceutical Research & Development: As a key investigational compound for studying the role of the PGD2/CRTH2 pathway in allergic and inflammatory diseases such as asthma, allergic rhinitis, and atopic dermatitis.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and safety profiles of CRTH2 antagonism.
• Clinical Trial Material (CTM): Serves as an active pharmaceutical ingredient (API) in the synthesis of formulations for human clinical trials.
• Mechanism of Action Studies: A critical tool for biochemical and cellular assays to understand receptor binding and downstream signaling events.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related substances.
• Hair Loss Research: Investigated for its potential application in addressing hair loss conditions like androgenetic alopecia, due to its anti-inflammatory effects on the hair follicle microenvironment.

Basic Information

Product Name	Setipiprant
CAS No.	866460-33-5
Molecular Formula	C₂₃H₂₅ClN₂O₃
Molecular Weight	412.91 g/mol
Synonyms	ACT-129968; 2-[2-(1-Naphthyl)ethyl]-6-(4-chlorophenoxy)pyridine-3-acetic acid; 6-(4-Chlorophenoxy)-2-(2-naphthalen-1-ylethyl)pyridine-3-acetic acid; NDI-034858; TM30089; CRTH2 antagonist; PGD2 receptor antagonist
EINECS	Contact for details

Quality Control

Our Setipiprant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.