Description

p-Coumaric Acid 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is a high-purity, synthetically derived chemical intermediate, specifically a glucuronide conjugate of p-coumaric acid. This compound is critical for researchers and manufacturers requiring a stable, protected precursor for advanced biochemical synthesis and metabolic studies. It is primarily utilized in the pharmaceutical and nutraceutical industries for the development of novel drug candidates, prodrugs, and as a reference standard in analytical chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents and prodrugs, particularly for enhancing bioavailability.
• Metabolite Reference Standard: Used as an analytical standard in LC-MS, HPLC, and other chromatographic methods for the quantification of p-coumaric acid metabolites in biological samples.
• Biochemical Research: Employed in enzymatic and metabolic pathway studies to investigate glucuronidation processes and phase II metabolism.
• Nutraceutical Development: Acts as a precursor for the formulation of advanced dietary supplements with targeted delivery mechanisms.
• Cosmetic Science: Investigated for use in stabilizing active phenolic compounds in advanced skincare formulations.

Basic Information

Product Name	p-Coumaric Acid 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester
CAS No.	866417-47-2
Molecular Formula	C22H24O13
Molecular Weight	496.42 g/mol
Synonyms	Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-((E)-3-(4-hydroxyphenyl)acryloyloxy)tetrahydro-2H-pyran-2-carboxylate; p-Coumaric Acid Glucuronide Methyl Ester Triacetate; 4-Coumaric Acid 2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid Methyl Ester; (E)-3-(4-Hydroxyphenyl)acrylic Acid 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester; p-Coumaroylglucuronic Acid Methyl Ester Triacetate
EINECS	Contact for details

Quality Control

Our p-Coumaric Acid 2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality control includes identification by spectroscopic methods (NMR, IR), purity assessment by HPLC, and control of residual solvents. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.