Description

L-745,870 Trihydrochloride is a high-purity, small molecule chemical compound primarily utilized as a potent and selective research tool in neuroscience and pharmacology. Its core value lies in its specific biological activity, enabling precise investigation into receptor mechanisms and signaling pathways. This product is essential for pharmaceutical R&D, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutic agents for central nervous system disorders.

Application

• Pharmacological Research: Used as a selective receptor antagonist in in vitro and in vivo studies to elucidate biological functions and validate drug targets.
• Neuroscience Studies: Critical for investigating neurotransmitter systems, particularly in models related to behavior, cognition, and neurological diseases.
• Drug Discovery & Development: Serves as a key reference standard and biochemical tool in high-throughput screening (HTS) and lead optimization phases.
• Academic & Institutional Research: Supports fundamental scientific research in university and government laboratories for peer-reviewed publications.
• Biochemical Assay Development: Employed in the development and validation of cell-based and biochemical assays to study receptor-ligand interactions.
• Preclinical Studies: Utilized in animal model research to assess efficacy, pharmacokinetics, and safety profiles of potential drug candidates.

Basic Information

Product Name	L-745,870 Trihydrochloride
CAS No.	866021-03-6
Molecular Formula	C₂₀H₂₅Cl₃N₄O
Molecular Weight	443.79 g/mol
Synonyms	L-745870; L745870; L 745870; 3-[(4-(4-Chlorophenyl)piperazin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridine trihydrochloride; 1-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]-4-(4-chlorophenyl)piperazine trihydrochloride; (1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl-4-(4-chlorophenyl)piperazine trihydrochloride
EINECS	Contact for details

Quality Control

Our L-745,870 Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. Comprehensive Certificates of Analysis (COA) detailing purity, residual solvents, and other critical parameters are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.