Description

3-Fluoro-1,2-Dihydropyridine-2-Thione is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique sulfur and fluorine-containing scaffold, which is pivotal for modulating the electronic and steric properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the design of activity-based probes and molecular tags for studying enzyme mechanisms and protein interactions.
• Catalyst Ligand Development: The thione and pyridine moieties can be utilized to develop novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Research: A valuable starting material for custom synthesis projects and discovery chemistry services targeting fluorinated heterocycles.

Basic Information

Product Name	3-Fluoro-1,2-Dihydropyridine-2-Thione
CAS No.	865663-90-7
Molecular Formula	C5H4FNS
Molecular Weight	129.16 g/mol
Synonyms	3-Fluoro-2-thioxo-1,2-dihydropyridine; 3-Fluoro-2-mercaptopyridine; 3-Fluoro-2-pyridinethione; 3-Fluoro-1H-pyridine-2-thione; 3-Fluoropyridine-2(1H)-thione; 2-Mercapto-3-fluoropyridine; 3-Fluoro-2-pyridinethiol
EINECS	Contact for details

Quality Control

Our 3-Fluoro-1,2-Dihydropyridine-2-Thione is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.