Description

2-(2,2-Difluoroethoxy)-6-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride is a high-purity, multi-fluorinated sulfonyl chloride building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique fluorine-containing substituents impart desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex sulfonamide and sulfonate derivatives.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel sulfonamide-based drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and advanced materials with specific surface properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes and affinity labels for studying enzyme function and protein interactions in biochemical research.
• Ligand Synthesis for Catalysis: Utilized to prepare sophisticated sulfonated ligands for metal-organic frameworks (MOFs) and asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	2-(2,2-Difluoroethoxy)-6-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride
CAS No.	865352-01-8
Molecular Formula	C9H6ClF5O3S
Molecular Weight	324.65 g/mol
Synonyms	6-(Trifluoromethyl)-2-(2,2-difluoroethoxy)benzenesulfonyl chloride; 2-(2,2-Difluoroethoxy)-α,α,α-trifluoro-o-toluenesulfonyl chloride; 1-(Difluoroethoxy)-2-(trifluoromethyl)-4-sulfonylchloridobenzene; 865352-01-8; Benzene-1-sulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-; o-Toluenesulfonyl chloride, 2-(2,2-difluoroethoxy)-α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-(2,2-Difluoroethoxy)-6-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride is produced and tested under a strict quality management system. We guarantee high purity and lot-to-lot consistency through rigorous analytical protocols including HPLC, GC, NMR, and Karl Fischer titration. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.