Description

2-(Difluoromethoxy)Pyridine is a specialized fluorinated pyridine derivative, a key building block in advanced organic synthesis. This compound is valued for its unique difluoromethoxy moiety, which can significantly alter the physicochemical and metabolic properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a critical strategy for optimizing potency and stability.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic materials, such as liquid crystals or polymers, for electronic and optical applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Difluoromethoxy)Pyridine
CAS No.	865075-07-6
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	Pyridine, 2-(difluoromethoxy)-; 2-(Difluoromethoxy)pyridine; 2-Pyridyl difluoromethyl ether; Difluoromethoxypyridine; 865075-07-6; 2-Difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.