Description

Benzenesulfonyl Fluoride, 2-Chloro- is a specialized organosulfur compound featuring a sulfonyl fluoride group activated by an adjacent chlorine substituent. This molecular architecture makes it a highly reactive and valuable synthetic intermediate and click chemistry reagent, particularly in the development of covalent inhibitors. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise, high-purity building blocks for drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted covalent inhibitors.
• Chemical Biology & Proteomics: Used as a reactive probe in activity-based protein profiling (ABPP) and for studying enzyme mechanisms via sulfonyl fluoride-based warheads.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and pesticides requiring sulfonamide or sulfonate functionalities.
• Material Science: Monomer or cross-linking agent for the development of specialty polymers and functional materials.
• Sulfonylation Reagent: Employed in organic synthesis to introduce the benzenesulfonyl group under mild conditions.
• Bioconjugation: Facilitates the stable labeling and modification of biomolecules for diagnostic and therapeutic applications.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 2-Chloro-
CAS No.	864872-77-5
Molecular Formula	C6H4ClFO2S
Molecular Weight	194.61 g/mol
Synonyms	2-Chlorobenzenesulfonyl Fluoride; 1-Chloro-2-fluorosulfonylbenzene; o-Chlorobenzenesulfonyl Fluoride; 2-Chlorophenylsulfonyl Fluoride; Benzenesulfonyl fluoride, 2-chloro-; 2-Chloro-BSF; (2-Chlorophenyl)sulfonyl fluoride
EINECS	Contact for details

Quality Control

Every batch of Benzenesulfonyl Fluoride, 2-Chloro- is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards and provide comprehensive analytical data. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to minimize exposure to moisture and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.