Description

Nedd8 Inhibitor M22 CAS NO 864420-54-2 is a potent and selective small-molecule inhibitor of the NEDD8-activating enzyme (NAE), a key regulator of the neddylation pathway. This compound is a critical research tool for investigating protein degradation, cell cycle progression, and signal transduction mechanisms, offering high specificity to minimize off-target effects. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurodegenerative disease, and proteostasis research.

Application

• Biomedical Research: A fundamental tool for studying the neddylation pathway's role in protein stability, cell proliferation, and apoptosis.
• Oncology Target Validation: Used in preclinical studies to investigate the therapeutic potential of NAE inhibition in various cancer models, including solid tumors and hematological malignancies.
• Mechanistic Studies: Enables the dissection of cullin-RING ligase (CRL) function and its impact on substrate-specific ubiquitination and degradation.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays for novel NAE inhibitors.
• Neurodegenerative Disease Research: Applied in models to explore the link between protein neddylation, aggregate clearance, and diseases like Alzheimer's and Parkinson's.
• Inflammatory Pathway Analysis: Used to study the modulation of inflammatory responses through the inhibition of NF-κB pathway regulators.

Basic Information

Product Name	Nedd8 Inhibitor M22
CAS No.	864420-54-2
Molecular Formula	C₂₁H₂₀N₄O₃
Molecular Weight	376.41 g/mol
Synonyms	MLN4924; NAE Inhibitor MLN4924; Neddylation Inhibitor MLN4924; 6-(4-(Methylsulfonyl)phenyl)-N-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-2-carboxamide; Pevonedistat; TAK-924; (S)-MLN4924; NEDD8 Activating Enzyme Inhibitor
EINECS	Contact for details

Quality Control

Our Nedd8 Inhibitor M22 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.