Description

4-Isobutylphenylmagnesium Bromide, 0.50 M In 2-Methf is a high-purity Grignard reagent solution, specifically formulated for advanced synthetic chemistry applications. This product is valued for its role as a key aryl nucleophile in the construction of complex organic molecules, offering consistent reactivity and quality. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for coupling reactions and the synthesis of novel intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the introduction of the 4-isobutylphenyl moiety in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and plant growth regulators requiring specific aryl structures.
• Cross-Coupling Reactions: Serves as a critical reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and specialty polymers where the isobutylphenyl group modifies material properties.
• Nucleophilic Addition Reactions: Reacts with various electrophiles such as carbonyl compounds, epoxides, and alkyl halides to create new molecular architectures.
• Process Chemistry & Scale-Up: Provides a reliable and scalable solution for kilo-lab and pilot plant production of specialty chemicals.

Basic Information

Product Name	4-Isobutylphenylmagnesium Bromide, 0.50 M In 2-Methf
CAS No.	863780-45-4
Molecular Formula	C10H13BrMg
Molecular Weight	237.42 g/mol (for bromide salt)
Synonyms	Magnesium, bromo(4-isobutylphenyl)-; (4-Isobutylphenyl)magnesium bromide; 4-(2-Methylpropyl)phenylmagnesium bromide; p-Isobutylphenylmagnesium bromide; Grignard Reagent (4-isobutylphenyl); 863780-45-4; Bromo(4-isobutylphenyl)magnesium
EINECS	Contact for details

Quality Control

Every batch of our 4-Isobutylphenylmagnesium Bromide solution is manufactured and tested under stringent quality management systems. We ensure consistent molarity, purity, and reactivity through advanced analytical techniques including titration and GC analysis. A comprehensive Certificate of Analysis (COA) detailing concentration, identity, and impurity profile is provided with each shipment to guarantee it meets the exacting standards required for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. This product is both hygroscopic (moisture-sensitive) and easily oxidized; contact with air, moisture, or protic solvents must be strictly avoided to maintain stability and reactivity. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in 2-Methyltetrahydrofuran (2-MeTHF)
Assay (Titration)	0.48 - 0.52 M
Identification (IR)	Conforms to structure
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.