Description

4-Fluoro-2-Methylbenzyl Bromide is a versatile and high-purity benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its reactive benzylic bromide group and the strategic fluorine substitution, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated benzyl moiety.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials that incorporate fluorinated aromatic units.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research applications due to its reactive halogen functionality.
• Custom Synthesis and Scale-up: A reliable reagent for contract research organizations (CROs) and CDMOs performing custom synthesis from milligram to kilogram scale.

Basic Information

Product Name	4-Fluoro-2-Methylbenzyl Bromide
CAS No.	862539-91-1
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(Bromomethyl)-4-fluoro-2-methylbenzene; (4-Fluoro-2-methylphenyl)methyl bromide; 2-Methyl-4-fluorobenzyl bromide; α-Bromo-4-fluoro-2-methyltoluene; 4-Fluoro-2-methylbenzylbromide; 4-Fluoro-o-tolylmethyl bromide; 2-Methyl-4-fluorobenzylbromide
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-2-Methylbenzyl Bromide is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards where applicable, supporting your regulatory compliance needs from R&D through to commercial production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.