Description

Ly2228820 is a potent and selective small molecule inhibitor of the p38 MAP kinase, a key signaling protein involved in inflammatory pathways. This high-purity compound is critical for pharmaceutical research and development, particularly in the study of inflammatory diseases and cancer. It is primarily utilized by research scientists and process development chemists in the biotechnology and pharmaceutical industries for target validation, lead optimization, and preclinical studies.

Application

• Biochemical Research: Used as a selective tool compound to study the role of p38 MAPK in cellular signaling cascades and disease models.
• Drug Discovery: Serves as a reference standard and a starting point for the development of novel anti-inflammatory and anti-cancer therapeutics.
• Preclinical Studies: Employed in in vitro and in vivo experiments to evaluate the efficacy and mechanism of action of p38 inhibition.
• Process Chemistry: Used as an intermediate or reference material in the synthesis and scale-up of related kinase inhibitor candidates.
• Academic Research: A vital reagent for universities and research institutes investigating inflammation, immunology, and oncology pathways.

Basic Information

Product Name	Ly2228820
CAS No.	862507-23-1
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	LY-2228820; 5-(2,6-Dichloro-4-pyridinyl)-3-[(1S)-1-(4-fluorophenyl)ethyl]-1H-indazole; VX-702; BIRB 796 analog; p38 MAP kinase inhibitor; p38α inhibitor; Doramapimod analog; RWJ 67657 related compound
EINECS	Contact for details

Quality Control

Our Ly2228820 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.