Description

Chymase-In-1 CAS NO 862090-74-2 is a potent and selective small molecule inhibitor of the serine protease chymase. This compound is a critical research tool for investigating the role of chymase in various inflammatory and fibrotic disease pathways. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in the fields of drug discovery and preclinical development. Its high selectivity makes it invaluable for target validation studies and for exploring chymase as a therapeutic target.

Application

• Biochemical Research: Used as a selective inhibitor to study chymase enzyme kinetics, substrate specificity, and inhibition mechanisms in vitro.
• Cardiovascular Disease Models: Applied in research exploring chymase's role in hypertension, cardiac fibrosis, and abdominal aortic aneurysm development.
• Pulmonary & Allergic Disease Research: Investigated in studies of asthma, chronic obstructive pulmonary disease (COPD), and other inflammatory lung conditions where chymase activity is implicated.
• Dermatological Research: Utilized in models of skin fibrosis, wound healing, and inflammatory skin disorders.
• Medicinal Chemistry & Hit-to-Lead Optimization: Serves as a reference compound or starting point for the design and synthesis of novel chymase inhibitors.
• Target Validation: Employed in cellular and animal models to validate chymase as a pharmacologically relevant target for new therapeutic interventions.

Basic Information

Product Name	Chymase-In-1
CAS No.	862090-74-2
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	Chymase Inhibitor 1; 4-[[(5S)-3-(4-Chlorophenyl)-1-methyl-4,5-dihydro-1H-pyrazol-5-yl]oxy]benzenesulfonamide; 4-(((5S)-3-(4-Chlorophenyl)-1-methyl-4,5-dihydro-1H-pyrazol-5-yl)oxy)benzenesulfonamide; (S)-4-((3-(4-Chlorophenyl)-1-methyl-4,5-dihydro-1H-pyrazol-5-yl)oxy)benzenesulfonamide; TY-51023; UNII-8JQ5607E5S; Chymase-IN-1; CAS 862090-74-2
EINECS	Contact for details

Quality Control

Our Chymase-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.