Description

5-Bromo-4-Fluoro-2-Iodotoluene is a high-purity halogenated toluene derivative, serving as a critical multi-functional building block in advanced organic synthesis. Its unique combination of bromine, fluorine, and iodine substituents on the aromatic ring makes it an exceptionally versatile intermediate for introducing halogen diversity and enabling selective cross-coupling reactions. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic entities.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where halogenated aromatic cores are required for bioactivity.
• Material Science Research: Serves as a precursor for synthesizing specialized organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings due to the presence of iodine and bromine, allowing for sequential functionalization.
• Chemical Library Development: Employed in high-throughput and parallel synthesis to create diverse compound libraries for screening.
• Fluorinated Compound Synthesis: The fluorine atom provides a metabolic stability handle, making it valuable for creating fluorinated analogs in drug discovery.

Basic Information

Product Name	5-Bromo-4-Fluoro-2-Iodotoluene
CAS No.	861928-20-3
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	2-Iodo-5-bromo-4-fluorotoluene; 1-Bromo-2-fluoro-4-iodo-5-methylbenzene; 5-Bromo-4-fluoro-2-iodo-1-methylbenzene; Toluene, 5-bromo-4-fluoro-2-iodo-; 861928-20-3; Bromofluoroiodotoluene
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Fluoro-2-Iodotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements, from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging are performed under controlled lighting conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥98.0% / ≥99.0% (High Purity Grades Available)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.