Description

trans-7,8-Dihydroxy-7,8-Dihydrobenzo[A]Pyrene-D8 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry and toxicology research. This compound is essential for achieving precise quantification in mass spectrometry, enabling accurate tracking and analysis of its non-labeled counterpart and related metabolites. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in environmental monitoring, carcinogenicity studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of benzo[a]pyrene diol epoxide (BPDE) adducts and metabolites in complex biological matrices.
• Environmental Analysis: Enables accurate measurement of polycyclic aromatic hydrocarbon (PAH) exposure and metabolic activation in environmental and occupational health studies.
• Toxicology & Carcinogenesis Research: Serves as a key reference standard in studies investigating the metabolic pathways, DNA adduct formation, and carcinogenic mechanisms of benzo[a]pyrene.
• Biomarker Development: Facilitates the development and validation of sensitive analytical methods for PAH-derived biomarkers in human biomonitoring.
• Pharmaceutical Metabolism Studies (ADME): Employed in absorption, distribution, metabolism, and excretion (ADME) studies to understand the metabolic fate of PAH-related compounds.
• Quality Control in Analytical Laboratories: Provides a stable isotopic standard for method calibration, ensuring data accuracy and reproducibility in commercial and regulatory testing labs.

Basic Information

Product Name	trans-7,8-Dihydroxy-7,8-Dihydrobenzo[A]Pyrene-D8
CAS No.	861441-06-7
Molecular Formula	C20H6D8O2
Molecular Weight	~290.35 g/mol
Synonyms	trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene-d8; (+/-)-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene-d8; 7,8-Dihydroxy-7,8-dihydro-B[a]P-d8; BP-7,8-diol-d8; Benzo[a]pyrene-7,8-dihydrodiol-d8; B[a]P-7,8-diol-d8; Deuterated BPD; trans-BPDE precursor-d8
EINECS	Contact for details

Quality Control

Every batch of trans-7,8-Dihydroxy-7,8-Dihydrobenzo[A]Pyrene-D8 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and deuterium enrichment to meet the exacting standards of analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.