Description

Shepherdin is a synthetic peptidomimetic compound of significant interest in pharmaceutical research and development. This compound matters for its targeted mechanism of action as a selective inhibitor of the heat shock protein 90 (Hsp90) and its client protein interaction, offering a novel approach in therapeutic areas. It is primarily needed by researchers and manufacturers in the oncology and neurodegenerative disease sectors for preclinical and clinical studies. Its unique structure provides a valuable tool for investigating disease pathways and developing new treatment modalities.

Application

• Oncology Research: Investigated as a potential therapeutic agent in various cancer models due to its Hsp90 inhibition properties.
• Neurodegenerative Disease Studies: Used in research targeting conditions like Alzheimer's and Parkinson's disease, where protein misfolding is implicated.
• Pharmaceutical Intermediate: Serves as a key building block or reference standard in the synthesis of more complex drug candidates.
• Biochemical Research: Employed as a specific probe to study the Hsp90 molecular chaperone system and its role in cellular stress response.
• Preclinical Development: Utilized in animal studies to evaluate pharmacokinetics, efficacy, and safety profiles of novel treatment concepts.
• Academic Research: A critical reagent for universities and institutes exploring apoptosis, cell signaling, and protein degradation pathways.

Basic Information

Product Name	Shepherdin
CAS No.	861224-28-4
Molecular Formula	C34H56N10O8
Molecular Weight	732.88 g/mol
Synonyms	Shepherdin (Hsp90 inhibitor); Hsp90 Antagonist Shepherdin; 5-Isoquinolinesulfonamide derivative; KU-174; Antagonist of Hsp90-Survivin Interaction; Shepherdin peptide mimetic; Hsp90-Survivin disruptor; Research compound 861224-28-4
EINECS	Contact for details

Quality Control

Our Shepherdin is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under desiccant to prevent moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.