Description

A2764 Dihydrochloride - Tresk Inhibitor A2764 is a potent and selective small molecule inhibitor of the TWIK-related spinal cord potassium (TresK) channel. This compound is a critical research tool for investigating the role of TresK channels in pain signaling and neuronal excitability, offering significant value for neuroscience and analgesic drug discovery. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on ion channel biology and the development of novel pain therapeutics.

Application

• Neuroscience Research: Fundamental tool for studying the physiological and pathological roles of TresK (KCNK18) channels in the central and peripheral nervous systems.
• Pain Pathway Investigation: Used in in vitro and in vivo models to elucidate mechanisms of migraine and other pain disorders where TresK channels are implicated.
• Ion Channel Screening: Serves as a reference compound in high-throughput screening (HTS) assays to identify new modulators of potassium channel activity.
• Drug Discovery & Development: A key pharmacological probe for target validation and the preclinical development of next-generation analgesic agents.
• Cellular Electrophysiology: Essential for patch-clamp experiments to characterize TresK channel currents and inhibition kinetics.
• Biochemical Assays: Used in studies to understand channel protein interactions and downstream signaling effects.

Basic Information

Product Name	A2764 Dihydrochloride - Tresk Inhibitor A2764
CAS No.	861038-72-4
Molecular Formula	C₁₉H₂₀Cl₂N₄O₃
Molecular Weight	423.29 g/mol
Synonyms	A-2764; A 2764; TresK Inhibitor A2764; 2-[(5-Chloro-2-methoxyphenyl)amino]-N-[(2,4-dimethoxyphenyl)methyl]pyrimidine-4-carboxamide dihydrochloride; KCNK18 Inhibitor A2764; TWIK-related spinal cord K+ channel inhibitor A2764
EINECS	Contact for details

Quality Control

Our A2764 Dihydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.