Description

Naronapride Dihydrochloride CAS NO 860169-57-9 is a high-purity pharmaceutical intermediate and research chemical. This compound is critical for the development and production of novel gastrointestinal prokinetic agents, targeting specific serotonin receptors. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in drug discovery and development.

Application

• Primary active pharmaceutical ingredient (API) or key intermediate in the synthesis of gastrointestinal motility drugs.
• Pharmacological research tool for studying 5-HT4 receptor agonists and their effects on digestive system disorders.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Preclinical and clinical research material for investigating treatments for gastroparesis, constipation-predominant irritable bowel syndrome (IBS-C), and functional dyspepsia.
• Chemical building block for the development of new chemical entities (NCEs) with prokinetic activity.

Basic Information

Product Name	Naronapride Dihydrochloride
CAS No.	860169-57-9
Molecular Formula	C23H30Cl2N4O3
Molecular Weight	505.42 g/mol
Synonyms	Naronapride HCl; ATI-7505; (3S,4R)-3-[(4-Amino-5-chloro-2-methoxyphenyl)methyl]-4-(3-methoxypropyl)-1-(2-methylbenzoyl)piperidine dihydrochloride; (3S,4R)-3-[(4-Amino-5-chloro-2-methoxyphenyl)methyl]-4-(3-methoxypropyl)-1-(o-toluoyl)piperidine dihydrochloride; UNII-8F1N5VK1P0; 1-(2-Methylbenzoyl)-3-[(4-amino-5-chloro-2-methoxyphenyl)methyl]-4-(3-methoxypropyl)piperidine dihydrochloride
EINECS	Contact for details

Quality Control

Our Naronapride Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications. We support development projects with material suitable for use under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.