Description

1-Methyl-1H-Indole-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, a crucial building block in advanced organic synthesis. Its primary value lies in its role as a versatile sulfonylation reagent, enabling the efficient introduction of the sulfonamide functional group into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with sulfonamide moieties.
• Material Science Research: Employed in the creation of specialty polymers and functional materials requiring specific sulfonamide linkages.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses producing bespoke organic compounds for clients.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	1-Methyl-1H-Indole-5-Sulfonyl Chloride
CAS No.	859850-75-2
Molecular Formula	C9H8ClNO2S
Molecular Weight	229.68 g/mol
Synonyms	5-(Chlorosulfonyl)-1-methyl-1H-indole; 1-Methylindole-5-sulfonyl chloride; 1-Methyl-5-indolesulfonyl chloride; 1H-Indole-5-sulfonyl chloride, 1-methyl-; 859850-75-2; 5-Sulfonyl chloride-1-methylindole; N-Methylindole-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Indole-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.