Description

4-Isoxazolesulfonyl Chloride, 3-Methyl- CAS NO 858489-87-9 is a high-purity, reactive sulfonyl chloride derivative based on the 3-methylisoxazole heterocyclic scaffold. This compound serves as a critical building block in modern organic synthesis, enabling the efficient introduction of the isoxazole-sulfonamide moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing sulfonamide-based drug candidates, particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the isoxazole ring confers specific biological activity.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Material Science: Employed in the synthesis of functional polymers and advanced materials with tailored sulfonamide properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring this specialized sulfonyl chloride.

Basic Information

Product Name	4-Isoxazolesulfonyl Chloride, 3-Methyl-
CAS No.	858489-87-9
Molecular Formula	C4H4ClNO3S
Molecular Weight	181.60 g/mol
Synonyms	3-Methylisoxazole-4-sulfonyl chloride; 3-Methyl-4-isoxazolesulfonyl chloride; 3-Methyl-1,2-oxazole-4-sulfonyl chloride; 4-Isoxazolesulfonyl chloride, 3-methyl-; 3-Methyl-4-sulfonylchloride isoxazole; 858489-87-9; 3-Methyl-isoxazol-4-ylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Isoxazolesulfonyl Chloride, 3-Methyl- is manufactured and tested under strict quality management systems. We ensure high purity and consistency through comprehensive analytical techniques including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.