Description

2-Bromo-5-Fluorobenzyl Chloride is a versatile and highly reactive halogenated benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the benzyl chloride moiety acts as an excellent electrophile for alkylation, and the bromo and fluoro substituents provide unique electronic and steric properties for further functionalization. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active molecules, particularly for central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that leverage the fluorine atom for enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Intermediate for synthesizing functionalized aromatic monomers intended for high-performance polymers and liquid crystals.
• Chemical Biology Probes: Serves as a starting material for creating fluorescent tags or affinity probes to study biological systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	2-Bromo-5-Fluorobenzyl Chloride
CAS No.	857276-61-0
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-5-chlorobenzene; (2-Bromo-5-fluorophenyl)methyl chloride; α-Chloro-2-bromo-5-fluorotoluene; 2-Bromo-5-fluoro-benzylchloride; 5-Fluoro-2-bromobenzyl chloride; Benzene, 1-(bromomethyl)-2-fluoro-5-chloro-; 2-Fluoro-5-bromobenzyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluorobenzyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality commitment supports compliance with relevant guidelines for pharmaceutical development (ICH Q7).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.