Description

Tie-2Inhibitor13 CAS NO 857250-95-4 is a potent and selective small molecule inhibitor targeting the Tie-2 (TEK) receptor tyrosine kinase. This compound is critical for researchers and developers in the life sciences sector, as it provides a precise tool for modulating angiogenesis-related signaling pathways. It is primarily utilized in pharmaceutical R&D for the development of novel oncology therapeutics and in academic research for studying vascular biology and tumor microenvironment interactions.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and preclinical development of anti-cancer drugs targeting angiogenesis.
• Oncology Studies: Used in in vitro and in vivo models to investigate the role of the Tie-2 signaling axis in tumor growth, metastasis, and vascular normalization.
• Biochemical Assays: Serves as a selective inhibitor in high-throughput screening (HTS) and enzyme activity assays to characterize Tie-2 kinase function and inhibitor potency.
• Academic & Institutional Research: Employed in fundamental research exploring endothelial cell biology, lymphangiogenesis, and the pathophysiology of vascular diseases.
• Preclinical Candidate Optimization: Utilized in structure-activity relationship (SAR) studies and lead optimization programs to develop next-generation kinase inhibitors.

Basic Information

Product Name	Tie-2Inhibitor13
CAS No.	857250-95-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tie-2 Inhibitor 13; Tie2 Inhibitor 13; 857250-95-4; Tie-2 Kinase Inhibitor; Angiopoietin Receptor Inhibitor; TEK Inhibitor; Tie-2/ANG Receptor Tyrosine Kinase Inhibitor; (Chemical name available upon request)
EINECS	Contact for details

Quality Control

Every batch of Tie-2Inhibitor13 is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.