Description

2-Bromo-6-Chlorobenzotrifluoride is a versatile halogenated benzotrifluoride derivative, a key building block in advanced organic synthesis. Its value lies in the trifluoromethyl group, which imparts unique electronic and lipophilic properties, and the strategically placed bromo and chloro substituents, which offer distinct sites for selective cross-coupling and substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a benzotrifluoride scaffold.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental stability.
• Material Science Building Block: Employed in the development of advanced polymers, liquid crystals, and electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromine atom serves as an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The chlorine atom can be selectively displaced by various nucleophiles, allowing for further functionalization of the aromatic ring.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Bromo-6-Chlorobenzotrifluoride
CAS No.	857061-44-0
Molecular Formula	C7H3BrClF3
Molecular Weight	259.45 g/mol
Synonyms	1-Bromo-3-chloro-2-(trifluoromethyl)benzene; 2-Bromo-6-chloro-α,α,α-trifluorotoluene; 2-Bromo-6-chloro(trifluoromethyl)benzene; 3-Chloro-2-trifluoromethylbromobenzene; Benzene, 1-bromo-3-chloro-2-(trifluoromethyl)-; 2-Chloro-6-bromobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Chlorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.