Description

S-(-)-7-Desmethyl-8-Nitro Blebbistatin is a potent and highly selective small-molecule inhibitor of non-muscle myosin II (NMM II) ATPase activity. This compound is a crucial research-grade chemical tool for investigating cytoskeletal dynamics, cell division, and mechanobiology in various cellular and biochemical assays. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for studying cell motility, morphology, and contractility.

Application

• Biochemical Research: As a selective inhibitor to study the specific functions of non-muscle myosin II isoforms (NMM II-A, II-B, II-C) in vitro.
• Cell Biology Studies: For probing the role of myosin II in cytokinesis, cell adhesion, migration, and maintaining cell cortical tension.
• Mechanobiology Investigations: Used in research focused on how cells sense and respond to mechanical forces and substrate stiffness.
• Pharmaceutical Screening: Serves as a reference compound or tool in high-throughput screening assays to identify novel modulators of the myosin pathway.
• Neuroscience Research: Applied in studies of neuronal growth cone dynamics and synaptic plasticity where myosin II activity is involved.
• Cardiovascular Research: For investigating the role of non-muscle myosin in vascular smooth muscle cell function and endothelial barrier regulation.

Basic Information

Item	Detail
Product Name	S-(-)-7-Desmethyl-8-Nitro Blebbistatin
CAS No.	856925-75-2
Molecular Formula	C18H14BrN3O4
Molecular Weight	416.23 g/mol
Synonyms	(-)-Blebbistatin; (S)-(-)-Blebbistatin; S-Blebbistatin; (S)-7-Desmethyl-8-nitroblebbistatin; 7-Desmethyl-8-nitroblebbistatin; Myosin II Inhibitor; NMM II Inhibitor; 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxy-6-methoxy-7-methyl-5-isoquinolinol (related core structure name)
EINECS	Contact for details

Quality Control

Our S-(-)-7-Desmethyl-8-Nitro Blebbistatin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.