Description

Deoxyblebbistatin is a potent and selective non-muscle myosin II (NMMII) inhibitor, structurally related to blebbistatin but with distinct photostability and solubility properties. This compound is a critical research tool for studying cytoskeletal dynamics, cell division, and mechanobiology in various biological systems. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies focused on developing novel therapeutics targeting myosin-related pathways.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of non-muscle myosin II in cellular processes such as cytokinesis, cell migration, and adhesion.
• Drug Discovery: Serves as a key pharmacological tool and lead compound in screening assays for developing new anti-cancer or anti-fibrotic agents targeting myosin ATPase activity.
• Cell Biology Studies: Applied in live-cell imaging and in vitro experiments to investigate cytoskeleton organization and force generation without the phototoxicity concerns associated with blebbistatin.
• Mechanobiology: Utilized to modulate cellular tension and understand mechanotransduction signaling pathways in stem cell differentiation and tissue engineering.
• Neuroscience Research: Employed to examine the role of myosin II in neuronal growth cone dynamics, synaptic plasticity, and axonal transport.
• Cardiovascular Research: Used to study myosin II function in vascular smooth muscle cell contraction and endothelial barrier function.

Basic Information

Product Name	Deoxyblebbistatin
CAS No.	856925-72-9
Molecular Formula	C₁₈H₁₆N₂O₂
Molecular Weight	292.33 g/mol
Synonyms	(S)-(-)-Deoxyblebbistatin; (-)-Deoxyblebbistatin; (S)-Deoxyblebbistatin; 4-[(1S)-1-Hydroxy-3-methylbutyl]-2-methyl-N-(1-phenylethyl)-1,3-thiazole-5-carboxamide; Blebistatin derivative; NMMII inhibitor; Myosin II ATPase inhibitor
EINECS	Contact for details

Quality Control

Our Deoxyblebbistatin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.