Description

5-Ethynyl-2-Fluoropyridine is a high-value fluorinated pyridine derivative featuring a reactive ethynyl group. This compound serves as a critical building block in modern organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and click chemistry reactions. It is primarily utilized by pharmaceutical R&D teams and advanced material scientists for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a tagging reagent for bio-conjugation and probe development via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Organic Ligand Precursor: Used to synthesize novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying fluorination effects and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	5-Ethynyl-2-Fluoropyridine
CAS No.	853909-08-7
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	2-Fluoro-5-ethynylpyridine; 5-Ethynyl-2-fluoropyridine; 2-Fluoro-5-ethynylpyridine; 2-Fluoropyridin-5-ylacetylene; 5-Ethynyl-2-fluoro-pyridine; Pyridine, 5-ethynyl-2-fluoro-; 853909-08-7
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.