Description

Abt 737 CAS NO 852808-04-9 is a potent and selective small-molecule inhibitor of the anti-apoptotic Bcl-2 family protein Mcl-1. This compound is a critical research tool for studying programmed cell death pathways and their role in diseases like cancer. It is primarily utilized by researchers in pharmaceutical R&D and academic institutions for target validation, mechanism-of-action studies, and as a lead compound in oncology drug discovery programs.

Application

• Biochemical Research: Used as a specific probe to investigate the biological function of Mcl-1 in apoptosis signaling pathways.
• Cancer Research: Employed in in vitro and in vivo studies to evaluate the therapeutic potential of Mcl-1 inhibition in various cancer cell lines and models.
• Drug Discovery & Development: Serves as a reference standard and a starting point for the design and synthesis of novel oncology therapeutics targeting Bcl-2 family proteins.
• Mechanistic Studies: Facilitates the study of drug resistance mechanisms, particularly those involving the upregulation of Mcl-1 in response to other chemotherapeutic agents.
• High-Throughput Screening (HTS): Used as a control compound in assays designed to discover new Mcl-1 inhibitors or modulators of apoptosis.

Basic Information

Product Name	Abt 737
CAS No.	852808-04-9
Molecular Formula	C42H45ClN6O5S2
Molecular Weight	813.43 g/mol
Synonyms	ABT-737; A-779667; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-(4-morpholinyl)-1-[(phenylthio)methyl]-2-butanyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide; Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-(4-morpholinyl)-1-[(phenylthio)methyl]-2-butanyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-
EINECS	Contact for details

Quality Control

Our Abt 737 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.