Description

Necrostatin-2 S Enantiomer CAS NO 852391-20-9 is the S-enantiomer of Necrostatin-2, a potent and selective inhibitor of receptor-interacting protein 1 (RIP1) kinase, a key mediator of necroptosis. This high-purity enantiomer is essential for precise biochemical and pharmacological research, enabling the study of chirality-dependent effects in programmed cell death pathways. It is a critical research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel therapeutics for inflammatory, neurodegenerative, and ischemic diseases.

Application

• Biochemical Research: Used as a selective RIP1 kinase inhibitor to study the molecular mechanisms of necroptosis (programmed necrosis).
• Pharmaceutical R&D: Serves as a key reference standard and lead compound in drug discovery programs targeting inflammatory and degenerative disorders.
• Cell Biology Studies: Employed in in vitro cell culture models to investigate cell death pathways and evaluate cytoprotective effects.
• Neuroscience Research: Applied in models of stroke, traumatic brain injury, and neurodegenerative diseases like ALS and Alzheimer's to explore necroptosis inhibition.
• Inflammation & Immunology: Utilized to dissect the role of RIP1 in inflammatory signaling cascades and immune cell regulation.
• Preclinical Development: Acts as a pharmacological tool in animal disease models to validate therapeutic targets related to necroptosis.

Basic Information

Item	Detail
Product Name	Necrostatin-2 S Enantiomer
CAS No.	852391-20-9
Molecular Formula	C₁₃H₁₃N₃O₂S
Molecular Weight	275.33 g/mol
Synonyms	Necrostatin-2 (S-isomer); (S)-Necrostatin-2; (S)-5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-[(1H-Indol-3-yl)methyl]-3-methyl-2-thioxo-4-imidazolidinone, (4S)-; RIP1 Kinase Inhibitor (S-enantiomer); Nec-2 S-Enantiomer; Necroptosis Inhibitor-2 (S-form)
EINECS	Contact for details

Quality Control

Our Necrostatin-2 S Enantiomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and identity verification by spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.