Description

Flt3 Inhibitor Iii CAS NO 852045-46-6 is a potent and selective small molecule inhibitor of the FMS-like tyrosine kinase 3 (FLT3) receptor. This compound is of significant value in biochemical and pharmacological research for its role in studying hematopoiesis and oncogenic signaling pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted therapies for acute myeloid leukemia (AML) and other myeloproliferative disorders.

Application

• Biochemical Research: Used as a selective tool compound to study FLT3 kinase signaling and its downstream effects in cellular models.
• Oncology Research: Critical for in vitro and in vivo studies investigating the role of FLT3 mutations in the pathogenesis and progression of acute myeloid leukemia (AML).
• Drug Discovery & Development: Serves as a reference standard and a lead compound in high-throughput screening and structure-activity relationship (SAR) studies for novel FLT3 inhibitors.
• Pharmacology Studies: Employed to assess the efficacy, selectivity, and potential resistance mechanisms of FLT3-targeted therapeutic agents.
• Cell Biology: Utilized to modulate FLT3 activity in primary cells and cell lines to understand its function in normal and malignant hematopoiesis.

Basic Information

Product Name	Flt3 Inhibitor Iii
CAS No.	852045-46-6
Molecular Formula	C₂₃H₂₀N₈O
Molecular Weight	424.46 g/mol
Synonyms	FLT3 Inhibitor III; 6-Ethyl-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)-5-(pyridin-4-yl)pyrazine-2-carboxamide; Quizartinib analog; AC220 analog; 852045-46-6; FLT3 Tyrosine Kinase Inhibitor III; UNII-8V4X1F1K7P
EINECS	Contact for details

Quality Control

Our Flt3 Inhibitor Iii is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.