Description

Seladelpar is a potent and selective peroxisome proliferator-activated receptor delta (PPARδ) agonist, representing a significant advancement in targeted therapeutic research. This compound is of critical importance for its potential in treating metabolic and inflammatory liver diseases, such as primary biliary cholangitis (PBC) and nonalcoholic steatohepatitis (NASH). Pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in metabolic disorder research are the primary users of this high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Pharmaceutical R&D: Serves as a key reference standard and intermediate in the development of novel PPARδ-targeted therapeutics.
• Metabolic Disease Research: Used in preclinical studies to investigate mechanisms and efficacy for conditions like PBC and NASH.
• Biochemical Assay Development: Employed as a selective agonist to validate and screen PPARδ activity in high-throughput assays.
• Academic Research: Utilized in university and institutional labs for fundamental studies on nuclear receptor signaling and liver pathophysiology.
• Process Chemistry: Acts as a critical building block for the synthesis and scale-up of clinical trial materials.
• Toxicology & Safety Studies: Required for generating impurity profiles and conducting ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) evaluations.

Basic Information

Product Name	Seladelpar
CAS No.	851528-79-5
Molecular Formula	C24H20F3NO4S
Molecular Weight	475.48 g/mol
Synonyms	MBX-8025; GW-501516 sulfonamide; 2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)acetic acid; 4-[(4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methanesulfinyl]phenoxyacetic acid; PPARδ Agonist MBX-8025
EINECS	Contact for details

Quality Control

Our Seladelpar is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.