Description

Berberine Hydrochloride is a quaternary ammonium salt derived from the isoquinoline alkaloid berberine, widely recognized for its broad-spectrum biological activity. This high-purity compound is essential for research and development, serving as a critical reference standard and active pharmaceutical ingredient. It is primarily utilized by the pharmaceutical, nutraceutical, and life science industries for applications in metabolic health, antimicrobial formulations, and biochemical research.

Application

• Pharmaceutical Intermediates: Serves as a key starting material or active pharmaceutical ingredient (API) in the formulation of drugs targeting metabolic syndrome, diabetes, and cardiovascular health.
• Nutraceutical & Dietary Supplements: Used as the primary bioactive component in capsules, tablets, and powders aimed at supporting healthy blood sugar and lipid metabolism.
• Biochemical & Life Science Research: Employed as a reference standard in HPLC/LC-MS analysis and as a tool compound for studying AMPK pathway activation, autophagy, and antimicrobial mechanisms.
• Antimicrobial Formulations: Incorporated into topical preparations and research solutions for its documented activity against various bacteria, fungi, and parasites.
• Veterinary Medicine: Used in animal health products for its gastrointestinal and antimicrobial properties.
• Cosmeceutical Ingredients: Found in skincare formulations for its anti-inflammatory and antioxidant benefits.

Basic Information

Product Name	Berberine Hydrochloride
CAS No.	633-65-8
Molecular Formula	C20H18ClNO4
Molecular Weight	371.81 g/mol
Synonyms	Berberine HCl; Berberine Chloride; Umbellatine Hydrochloride; Natural Yellow 18, chloride; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride; Berberinium Chloride
EINECS	211-195-9

Quality Control

Our Berberine Hydrochloride is manufactured under strict quality management systems. We offer grades compliant with USP, EP, and FCC monographs, ensuring suitability for pharmaceutical and nutraceutical applications. Every batch undergoes rigorous analytical testing including HPLC for assay and related substances, heavy metals screening, and microbiological examination. A comprehensive Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange-yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Microbiological Enumeration	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.