Description

7-Sulfo-Ursodeoxycholic Acid Disodium Salt is a chemically modified derivative of the primary bile acid ursodeoxycholic acid, featuring a sulfonate group at the 7-position. This modification significantly enhances its water solubility and alters its biochemical properties, making it a valuable intermediate for advanced pharmaceutical research and development. It is particularly sought after by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents and diagnostic compounds.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel bile acid analogs and hepatoprotective drugs.
• Biochemical Research: Used as a reference standard or probe in studies investigating bile acid metabolism, transporter interactions (e.g., NTCP, BSEP), and cholestatic liver diseases.
• Prodrug Development: The sulfonate group serves as a handle for creating water-soluble prodrugs of lipophilic active pharmaceutical ingredients (APIs).
• Diagnostic Agent Synthesis: Potential precursor for developing contrast agents or radiolabeled tracers for medical imaging, leveraging its specific biological pathway.
• Cell Culture & In Vitro Studies: Employed in cell-based assays to study the effects of sulfated bile acids on cell signaling, apoptosis, and inflammation.

Basic Information

Product Name	7-Sulfo-Ursodeoxycholic Acid Disodium Salt
CAS No.	191286-16-5
Molecular Formula	C24H38Na2O8S
Molecular Weight	540.59 g/mol
Synonyms	Ursodeoxycholic Acid 7-Sulfate Disodium Salt; 7-Sulfo-UDCA Disodium Salt; Disodium 3α,7β-dihydroxy-5β-cholan-24-oate 7-sulfate; 7-Sulfoursodeoxycholic Acid Disodium Salt; UDCA-7S Disodium Salt; 7β-Sulfo-3α,7β-dihydroxy-5β-cholan-24-oic Acid Disodium Salt; Sodium 7-Sulfoursodeoxycholate
EINECS	Contact for details

Quality Control

Our 7-Sulfo-Ursodeoxycholic Acid Disodium Salt is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting standards for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.