Description

(2S,4R)-4-Fluoropyrrolidine-2-Carboxamide CAS NO 851509-26-7 is a high-purity, chiral fluorinated pyrrolidine derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its unique stereochemistry and fluorine atom, which are instrumental in modulating the biological activity, metabolic stability, and bioavailability of drug candidates. This advanced pharmaceutical intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas like protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Serves as a critical scaffold in the construction of inhibitors for various proteolytic enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities for drug discovery programs.
• Peptidomimetics: Employed as a constrained, fluorinated analog of proline in the design of peptide-like molecules with enhanced drug-like properties.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective chemical transformations.

Basic Information

Product Name	(2S,4R)-4-Fluoropyrrolidine-2-Carboxamide
CAS No.	851509-26-7
Molecular Formula	C5H9FN2O
Molecular Weight	132.14 g/mol
Synonyms	(2S,4R)-4-Fluoropyrrolidine-2-carboxamide; 4-Fluoro-D-prolinamide; (2S,4R)-4-Fluoro-2-pyrrolidinecarboxamide; 4-Fluoro-L-prolinamide (ambiguous); 851509-26-7; Fluoropyrrolidine carboxamide; (4R)-4-Fluoropyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Fluoropyrrolidine-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.