Description

n-[(3Beta)-3-Hydroxy-28-Oxoolean-12-En-28-Yl]-L-Leucine is a high-purity, semi-synthetic derivative of oleanolic acid, a pentacyclic triterpenoid, conjugated with the amino acid L-leucine. This compound is valued for its role as a key intermediate in advanced pharmaceutical research, particularly in the development of novel therapeutic agents targeting metabolic and inflammatory pathways. It is primarily sought by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of bioactive natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those derived from triterpenoid scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop compounds with enhanced bioactivity and pharmacokinetic properties.
• Anti-inflammatory Agent Development: Investigated as a precursor for potential therapeutic agents targeting inflammatory diseases.
• Metabolic Disorder Research: Employed in research programs focused on diabetes, obesity, and related metabolic syndromes.
• Academic & Institutional Research: Utilized in university and government labs for biochemical and pharmacological studies of natural product derivatives.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-[(3Beta)-3-Hydroxy-28-Oxoolean-12-En-28-Yl]-L-Leucine
CAS No.	851475-43-9
Molecular Formula	C₃₆H₅₇NO₅
Molecular Weight	583.85 g/mol
Synonyms	Oleanolic Acid Leucine Conjugate; L-Leucine, N-[(3β)-3-hydroxy-28-oxoolean-12-en-28-yl]-; 28-Norolean-12-ene-3β,28-diol 28-Leucinate; 3β-Hydroxyolean-12-en-28-oic acid leucinamide; Oleanolic acid amide with leucine; (3β)-3-Hydroxyolean-12-en-28-oic acid leucinamide; Leucine-oleanolic acid conjugate
EINECS	Contact for details

Quality Control

Our n-[(3Beta)-3-Hydroxy-28-Oxoolean-12-En-28-Yl]-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.