Description

2,5-Difluoropyridine-3-Carboxylic Acid is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which enables precise molecular modifications essential for developing novel compounds with targeted properties. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, as well as by manufacturers of specialty chemicals and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Building Block: Utilized in medicinal and combinatorial chemistry for introducing fluorine atoms and carboxylic acid functionality into complex molecules.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on heterocyclic and fluorine chemistry.

Basic Information

Product Name	2,5-Difluoropyridine-3-Carboxylic Acid
CAS No.	851386-43-1
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	3-Carboxy-2,5-difluoropyridine; 2,5-Difluoronicotinic Acid; 2,5-Difluoropyridine-3-carboxylic acid; 851386-43-1; Difluoropyridinecarboxylic Acid; 3-Pyridinecarboxylic acid, 2,5-difluoro-
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine-3-Carboxylic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.