Description

4-Chloro-2,5-Difluoropyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique substitution pattern, offering precise reactivity for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Used to create sophisticated pyridine-based ligands for transition metal catalysis in fine chemical production.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Nucleophilic Aromatic Substitution: The chlorine and fluorine atoms provide distinct sites for selective substitution, enabling diverse chemical transformations.

Basic Information

Item	Details
Product Name	4-Chloro-2,5-Difluoropyridine
CAS No.	851386-40-8
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	2,5-Difluoro-4-chloropyridine; 4-Chloro-2,5-difluoropyridine; Pyridine, 4-chloro-2,5-difluoro-; 851386-40-8; 4-Chloro-2,5-difluoro-pyridine; 4-Chloro-2,5-difluoropyridine (CAS 851386-40-8); 2,5-Difluoro-4-chloro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and strong reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.