Description

5,6-Difluoropyridine-2-Carboxylic Acid is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluoropyridine scaffold, which is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals and organic semiconductors, due to its electron-withdrawing properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	5,6-Difluoropyridine-2-Carboxylic Acid
CAS No.	851386-38-4
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	2,3-Difluoropyridine-5-carboxylic Acid; 2-Carboxy-5,6-difluoropyridine; 5,6-Difluoropicolinic Acid; 5,6-Difluoro-2-pyridinecarboxylic Acid; Difluoropyridinecarboxylic Acid; Picolinic Acid, 5,6-difluoro-; 851386-38-4; 5,6-Difluoro-2-carboxypyridine
EINECS	Contact for details

Quality Control

Our 5,6-Difluoropyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.