Description

5-Iodo-2,3-Difluoropyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and iodine motifs for bioactivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Building block for synthesizing functionalized polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: Excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings due to the reactive iodo group.
• Fluorine Chemistry Studies: Used in research exploring the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Item	Details
Product Name	5-Iodo-2,3-Difluoropyridine
CAS No.	851386-35-1
Molecular Formula	C5H2F2IN
Molecular Weight	256.98 g/mol
Synonyms	2,3-Difluoro-5-iodopyridine; 5-Iodo-2,3-difluoropyridine; 2,3-Difluoro-5-iodo-pyridine; Pyridine, 5-iodo-2,3-difluoro-; 851386-35-1; 5-Iodo-2,3-difluoro-pyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2,3-Difluoropyridine is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your research and production needs. We provide comprehensive analytical data, including HPLC purity, NMR (1H, 13C, 19F) confirmation, and identity verification by FT-IR. A Certificate of Analysis (COA) detailing all specifications is available for each lot upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.