Description

Vx-765 CAS NO 851091-96-8 is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is a critical building block in the development of novel therapeutic agents, particularly for its role as a selective inhibitor. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality materials for drug discovery, process development, and advanced clinical studies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting specific disease pathways.
• Biochemical Research: Used as a selective enzyme inhibitor in proteomics and signal transduction pathway studies.
• Drug Discovery & Development: A vital tool compound for high-throughput screening (HTS) and lead optimization in preclinical research.
• Academic Research: Employed in university and institutional labs for investigating molecular mechanisms and validating new therapeutic targets.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for cGMP production of clinical trial materials.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in regulatory submissions.

Basic Information

Product Name	Vx-765
CAS No.	851091-96-8
Molecular Formula	C19H21N3O5S
Molecular Weight	403.45 g/mol
Synonyms	VX-765; Belnacasan; (2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S,3R)-4-ethoxy-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-oxobutan-2-yl]-5-sulfamoylpentanamide; ICE Inhibitor VX-765; Caspase-1 Inhibitor VX-765; Interleukin-1β Converting Enzyme Inhibitor VX-765
EINECS	Contact for details

Quality Control

Our Vx-765 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements, including cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.