Description

6-Trifluoromethyl-Nicotinic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the introduction of the trifluoromethyl group, which significantly alters the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Acts as a starting material for fluorinated liquid crystals, organic semiconductors, and other advanced functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.

Basic Information

Product Name	6-Trifluoromethyl-Nicotinic Acid Ethyl Ester
CAS No.	851070-23-0
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Ethyl 6-(trifluoromethyl)nicotinate; Ethyl 6-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-, ethyl ester; 6-Trifluoromethylnicotinic acid ethyl ester; 6-Trifluoromethyl-3-pyridinecarboxylic acid ethyl ester; 6-CF3-Nicotinic Acid Ethyl Ester; 6-Trifluoromethyl-pyridine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of 6-Trifluoromethyl-Nicotinic Acid Ethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and mass spectrometry, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.