Description

Pdk1 Inhibitor CAS NO 850717-64-5 is a potent and selective small molecule inhibitor of the 3-phosphoinositide-dependent protein kinase-1 (PDK1), a key regulator of the AGC kinase family and the PI3K/AKT signaling pathway. This compound is a critical research tool for investigating cellular processes related to cell growth, survival, and metabolism, with significant implications for understanding oncogenic signaling. It is primarily utilized by researchers and developers in pharmaceutical R&D, academic biochemistry, and oncology research for target validation and preclinical studies.

Application

• Biochemical Research: Used as a selective tool compound to study the role of PDK1 in the PI3K/AKT/mTOR signaling pathway in vitro.
• Cancer Research: Employed in cell-based assays to investigate the effects of PDK1 inhibition on tumor cell proliferation, survival, and apoptosis.
• Drug Discovery & Development: Serves as a reference standard and a starting point for the design and synthesis of novel therapeutic agents targeting PDK1.
• Signal Transduction Studies: Applied to elucidate downstream effects of PDK1 on various AGC kinases like PKB/AKT, SGK, and PKC.
• Academic & Institutional Labs: Utilized for fundamental research into metabolic regulation, diabetes, and cardiovascular diseases where PDK1 plays a role.

Basic Information

Product Name	Pdk1 Inhibitor
CAS No.	850717-64-5
Molecular Formula	C₂₁H₂₀N₈O₂
Molecular Weight	416.44 g/mol
Synonyms	PDK1 Inhibitor; 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; BX-795; BX 795; BX795; UNII-6P30VU16B2; 6P30VU16B2; CAS 850717-64-5
EINECS	Contact for details

Quality Control

Our Pdk1 Inhibitor is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.