Description

Gsk269962A CAS NO 850664-21-0 is a potent and selective small molecule inhibitor of ROCK (Rho-associated coiled-coil forming protein kinase), a key enzyme involved in regulating the actin cytoskeleton and cellular contraction. This compound is a critical research tool for investigating signaling pathways related to cell motility, morphology, and smooth muscle function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for preclinical studies in areas such as cardiovascular disease, neurological disorders, and cancer biology.

Application

• Biomedical Research: A key pharmacological tool for studying the ROCK signaling pathway and its role in cellular processes.
• Cardiovascular Research: Investigation of vascular smooth muscle contraction, hypertension, and atherosclerosis.
• Neurological Research: Exploration of neuronal growth cone collapse, axon guidance, and potential applications in spinal cord injury or stroke models.
• Oncology Research: Study of cancer cell invasion, metastasis, and tumor cell morphology regulated by the Rho/ROCK pathway.
• Ophthalmic Research: Research into intraocular pressure regulation and glaucoma, where ROCK inhibition is a therapeutic target.
• Fibrosis Research: Investigation of ROCK's role in organ fibrosis, including pulmonary, renal, and hepatic fibrosis.

Basic Information

Product Name	Gsk269962A
CAS No.	850664-21-0
Molecular Formula	C₂₀H₂₄N₄O₃
Molecular Weight	368.43 g/mol
Synonyms	GSK269962A; GSK-269962A; 4-Fluoro-5-[[(2S)-2-(1-methyl-1H-indazol-5-yl)pyrrolidin-1-yl]methyl]isoquinoline; (S)-4-Fluoro-5-((2-(1-methyl-1H-indazol-5-yl)pyrrolidin-1-yl)methyl)isoquinoline; ROCK Inhibitor GSK269962A; GSK 269962; GSK-269962
EINECS	Contact for details

Quality Control

Our Gsk269962A is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.